Figure 3. CGRP-LI in identified Aδ-fibre neurones.

Layout as in Fig. 2. Left, S1 DRG neurones labelled with LY; right, micrographs of the same DRG sections processed to show CGRP-LI. A, CGRP-LI negative HTM that had a typical superficial, distributed punctate receptive field (CV, 4 m s⁻¹). B, MH cell (mechanical-heat nociceptor) (CV, 1.8 m s⁻¹) that was unambiguously positive for CGRP-LI. The receptive field was superficial and punctate on the side of the upper leg, evoking a response to pressure with needle, pinch by fine forceps and noxious heat. C, section through the nucleus of a D-hair unit (CV, 3.1 m s⁻¹) that was negative for CGRP-LI. The unit had a receptive field on the thigh that gave vigorous responses to moving brush, skin stretch and sudden cooling. Scale bar in A applicable to all.