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. 2002 May 15;541(Pt 1):41–64. doi: 10.1113/jphysiol.2001.014001

Figure 1. Types of single-channel activity mediated by NMDA receptors in outside-out patches from P0 hippocampal granule cells.

Figure 1

Patches containing only high amplitude single-channel currents (A) and a mixture of high and low amplitude single-channel currents (B) were observed. Openings are downwards. Currents were low-pass filtered at 2 kHz (-3db, 8 pole Bessel filter) and digitized at 20 kHz. Each panel contains ten contiguous 500 ms sweeps of single-channel recording. The solution bathing the extracellular face of the patches contained glutamate (0.05 μM) and glycine (3 μM) as agonists plus the non-NMDA receptor antagonist DNQX (5 μM). Holding potential was −60 mV.