Figure 1. Activation of mechanosensitive (MS) channels in a typical cell-attached experiment on a K562 leukaemia cell.

The cell-attached mode was achieved using a pipette containing a solution that included Na⁺. A, representative single-current records showing the effect of negative pressure application at a membrane potential of 40 mV; the application and removal of suction are indicated by the arrows. B, corresponding amplitude histogram. C, the I-V relationship shows current reversal at about zero and a slight inward rectification. Unitary conductance, which was estimated in the range of negative potentials, was 26 pS.