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. 2002 Jun 1;541(Pt 2):545–559. doi: 10.1113/jphysiol.2001.015842

Figure 7. Consequences of increasing the initial RRP size on simulated STD.

Figure 7

A, change in release during 10 Hz simulation for control terminals (10 vesicles in the RRP, •) and terminals in which the initial RRP size was increased to 15 vesicles (○). Control steady state = 13.4 ± 0.4 %; RRP15 steady state = 12.6 ± 0.6 %. B, frequency dependence of the steady-state level of release during simulated STD with 10 (•) and 15 (○) vesicles in the RRP. Inset, fit of control (continuous line) and RRP 15 data (dashed line) with a Lorentzian function. The dotted line indicates the frequency resulting in 50 % depression. C, mean number of vesicles in RRP during simulated STD with 10 (•) and 15 (○) vesicles in RRP. Exponential fits of the data for 10 (continuous line) and 15 vesicles in the RRP (dotted line) are shown in A (double) and C (single).