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. 2002 Jun 1;541(Pt 2):351–366. doi: 10.1113/jphysiol.2002.017749

Figure 5. The guanylate cyclase inhibitor ODQ prevents SNP action.

Figure 5

A, during simultaneous application of SNP (200 μM) and ODQ (10 μM; right), L-channel activity is not significantly different from that in the presence of ODQ alone (left). Bottom traces are averaged currents from the same patch over 10 and 40 sweeps, respectively. Notice the close similarities between the two traces. B, NPo values versus time calculated from the same patch shown in A. Horizontal segments indicate the representative traces shown in A. C, mean NPo obtained by averaging data from 5 patches over 1 min (control + ODQ, ▪) and 30 s periods (SNP + ODQ, □), respectively. All the patches contained multichannel openings.