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. 2002 Jun 1;541(Pt 2):351–366. doi: 10.1113/jphysiol.2002.017749

Figure 7. SNP preserves its action even when the PKA inhibitor H89 prevents cAMP-mediated up-regulation of L-channel.

Figure 7

A, L-channel activity in a chromaffin cell incubated for 20 min with 1 μM H89 (left) is effectively inhibited by exposure to SNP (200 μM; right). Bottom traces are averaged currents obtained from 10 (control + H89) and 40 traces (SNP + H89) of the same patch. Notice the strong depression induced by SNP, which is comparable to that of Fig. 1. B and C show the time course of NPo and mean NPo derived from 6 patches following the same protocols as in Fig. 5. Horizontal segments in B indicate the representative traces shown in A. All the patches contained multichannel openings.