Figure 1. Ca2+ channel blockers increase the frequency of mIPSCs in dissociated neurons.
Nimodipine (100 μM, A), ω-conotoxin MVIIC (1.0 μM, B), ω-conotoxin GVIA (1.0 μM, C) and calciseptine (1.0 μM, D) were added to the external solution, starting at the time indicated by arrows. Note the resulting increase in mIPSC frequency. Current recorded with the postsynaptic membrane potential clamped at -4 mV. Currents presented in A and B were recorded from the same cell, C and D from two different cells.