Table 2.
Whole-cell outward current magnitude, τInact and τDeasct in olfactory bulb neurons chronically stimulated with 100 ng ml−1 NGF, BDNF or NT3
| 24 h | 72 h | >200h | |
|---|---|---|---|
| Peak current amplitude (pA) | |||
| Control | 1758 ± 190(14) | 3188 ± 533(6) | 3851 ± 345(10) |
| NGF | 2157 ± 156(10) | 3025 ± 328(7) | 3596 ± 155(5) |
| BDNF | 2407 ± 287(11) | 4428 ± 290(7)* | 4563 ± 306(6)* |
| NT3 | 2630 ± 346(9) | 2732 ± 350(6) | 3496 ± 305(5) |
| Current kinetic properties (ms) | |||
| Control | |||
| τInact | 183 ± 51(14) | 240 ± 50(6) | 171 ± 29 (10) |
| τDeact | 2 ± 0.4 | 2 ± 0.5 | 2 ± 0.4 |
| NGF | |||
| τInact | 152 ± 38 (10) | 179 ± 45(7) | 134 ± 8(5) |
| τDeact | 2 ± 0.4 | 2 ± 0.6 | 1 ± 0.1 |
| BDNF | |||
| τInact | 160 ± 37(11) | 120 ± 40(7)* | 117 ± 29(6)* |
| τDeact | 2 ± 0.3 | 2 ± 0.4 | 1 ± 0.1 |
| NT3 | |||
| τInact | 150 ± 34 (9) | 128 ± 33(6)* | 149 ± 37 (5) |
| τDeact | 2 ± 0.5 | 0.5 ± 0.1 | 1 ± 0.7 |
Voltage stimulation protocol and calculation of the kinetics of inactivation and deactivation as in Table 1. *Neurotrophin treatment is significantly different from control for a given biophysical property by AN OVA, completely randomized design, with SNK follow-up test at P < 0.05. Values represent means ± s.e.m. with the number of neurons sampled in parentheses.