Table 1.
Kinetic parameters of native and cloned K+ channels
Type 1 | TASK-1 | Type 2 | TASK-3 | Type 3 | TREK-2 | Type 4 | |
---|---|---|---|---|---|---|---|
Conductance (pS) | |||||||
60 mV | 8.6 ± 1.1 | 9.2 ± 1.1 | 16.3 ± 1.2 | 17.1 ± 1.4 | 67 ± 8 | 65 ± 6 | 30 ± 2 |
−60 mV | 15.6 ± 1.3 | 16.2 ± 1.3 | 33.0 ± 2.4 | 36.0 ± 2.4 | 107 ± 7 | 104 ± 6 | 32 ± 2 |
Mean open time (ms) | |||||||
(−60 mV) | 0.7 ± 0.1 | 0.8 ± 0.1 | 1.7 ± 0.1 | 1.8 ± 0.1 | 0.9 ± 0.1 | 1.0 ± 0.1 | 2.4 ± 0.2 |
Each value represents the mean ± s.d. of 3–6 values. When values determined for the Type 1 K+ channel and TASK-1, the Type 2 K+ channel and TASK-3, and the Type 3 K+ channel and TREK-2 were compared, none was significantly different from each other (P > 0.05). For more details, see text.