Table 2.
Responses to drugs or native and cloned K+ channels shown as percentage inhibition
| Type 1 | TASK-1 | Type 2 | TASK-3 | Type 3 | TREK-2 | Type 4 | |
|---|---|---|---|---|---|---|---|
| Ba2+ (3 mm) | 65 ± 8 | 69 ± 8 | 62 ± 5 | 58 ± 7 | 45 ± 12 | 52 ± 11 | 95 ± 3 |
| TEA (1 mm) | 6 ± 6 | 8 ± 7 | 3 ± 5 | 2 ± 3 | 2 ± 3 | 0 ± 3 | 90 ± 10 |
| 4-AP(out;1 mm) | 4 ± 6 | 5 ± 5 | 1 ± 4 | 0 ± 3 | 1 ± 3 | 0 ± 4 | 8 ± 9 |
| Apamin (out;100 nm) | 2 ± 5 | 3 ± 4 | 6 ± 7 | 5 ± 6 | 3 ± 4 | 1 ± 3 | 1 ± 4 |
| Quinidine (0.1 mm) | 45 ± 8 | 52 ± 6 | 40 ± 7 | 38 ± 6 | 8 ± 6 | 6 ± 4 | 86 ± 12 |
| Bupivacaine (0.1 mm) | — | — | 58 ± 11 | 54 ± 8 | 52 ± 6 | — | — |
| AA (10 or 20 μm) | 32 ± 6 | 36 ± 8 | 69 ± 6 | 63 ± 7 | (12 ± 4) | (16 ± 6) | (4.9 ± 1.7) |
| GTPγS(10 μm) | — | — | 32 ± 4 | 38 ± 6 | 10 ± 4 | 8 ± 3 | 5 ± 6 |
Each value represents the mean ± s.d. of 3–6 values. Each agent was applied to the cytoplasmic side of the membrane unless indicated otherwise. All mean values above 20 % were significantly different from their respective controls (P < 0.05). Values in parentheses indicate ‘fold’ increase, not percentage inhibition. For more details, see text. AA, arachidonic acid.