Figure 1.

The effect of noradrenaline on I_Cl(swell)

A, representative trace illustrating the increase of I_Cl(swell) produced by 10 μm noradrenaline. In all traces vertical deflections represent the ramp protocol from a holding potential of −50 mV and in this and subsequent figures the arrow to the left of the trace indicates zero current level. B, leak-subtracted current-voltage relationship (see Methods) of I_Cl(swell) evoked by 75 mm NaCl (•) and in the same hypotonic solution containing 10 μm noradrenaline (○). In this and subsequent figures mean current densities were calculated as pA pF⁻¹. Each point is the mean ±s.e.m. of 5 cells. C, representative trace illustrating the inhibitory effect of 10 μm noradrenaline on I_Cl(swell) in another cell. Note the oscillation of I_Cl(swell) as it is inhibited. D, leak-subtracted current-voltage relationship of I_Cl(swell) evoked by 75 mm NaCl (•) and in the same hypotonic solution containing 10 μm noradrenaline (○). Each point is the mean ±s.e.m. of 6 cells.