Figure 6.
Immunological blockade of fast-inactivating K+ currents in rabbit CB chemoreceptor cells
A-C, representative recordings of outward currents of chemoreceptor cells obtained with pulses to +40 mV, before (thick traces) and after (thin traces) 10 min of dialysis of antibodies raised against Kv1.4 (A), Kv3.4 (B) and Kv4.3 (C) subunits. The left upper panels show seal conditions of the control recordings for each trace (see Methods for details about the voltage protocol). D, plot of average (mean ± s.e.m.) effects of antibodies measuring I/I0 at 10 min of recording. Only the anti-Kv3.4 and Kv4.3 antibodies produced a significant reduction in this parameter.