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. 2002 Jul 15;542(Pt 2):567–581. doi: 10.1113/jphysiol.2002.019059

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© The Physiological Society 2002

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Effect of NMDA receptor block on spontaneous activity in agranular neocortex during disinhibition

A, examples of spontaneous field potential activity recorded during bath application of BMI plus CGP35348 (trace 1) and subsequent addition of APV (100 μm) (traces 2 and 3). The numbers on the upper single traces correspond to the activity shown below. The difference between 2 and 3 is the time after the beginning of APV application, which was 15 and 40 min, respectively. B, fast Fourier transform of single events recorded during BMI, BMI+CGP and BMI+CGP+APV (10 events per condition are averaged). Note the reduction in the power range between 10 and 15 Hz during application of APV and the simultaneous enhancement of the power range between 15 and 25 Hz. C, population data show a significant reduction in the power range between 10 and 15 Hz (*) with application of APV, but also a significant enhancement in the power range between 15 and 25 Hz (**) with APV. Data correspond to five experiments (10 events per condition) and are expressed as the percentage change from BMI alone.