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. 2002 Jul 15;542(Pt 2):567–581. doi: 10.1113/jphysiol.2002.019059

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Effect of the non-NMDA receptor antagonist CNQX on 10 Hz oscillations induced by disinhibition

A, upper panel, representative traces corresponding to single spontaneous events produced during application of BMI+CGP35348 and at different times after starting application of CNQX (10 μm). The numbers on the traces correspond to the time shown below. Lower panel, effect of CNQX on the amplitude of the initial large amplitude negative spike (filled circles) and on the small amplitude spikes that follow and form the 10 Hz oscillations (open squares). For the small spikes the amplitude of the largest event among them was always used. Note the rapid abolition of the small amplitude spikes. B, upper panel, representative traces corresponding to single spontaneous events produced during application of BMI+CGP35348 and at different times after starting application of CNQX (2 μm). Lower panel, effect of CNQX on the amplitude of the initial large amplitude negative spike (filled circles) and on the small amplitude spikes that follow and form the 10 Hz oscillations (open squares). Note the selective abolishment of the oscillation.