Figure 4. Suppression of macropatch currents in the inside-out mode by arachidonic acid was not affected by inhibitors of oxygenases that are involved in arachidonic acid metabolism.

A, effect of arachidonic acid in the presence of 20 μm indomethacin. B, effect of arachidonic acid in the presence of 20 μm NDGA. C, effect of arachidonic acid in the presence of 20 μm clotrimazole. D, inhibitory effect of arachidonic acid in the absence or presence of oxygenase inhibitors (mean ± s.e.m.). Percentage inhibition of macropatch currents by arachidonic acid in the presence or absence of oxygenase inhibitors was calculated from currents measured before application of arachidonic acid.