Figure 7. Inhibitory effects of the NO scavenger carboxy-PTIO and the soluble guanylate cyclase inhibitor (ODQ) on the SNP-induced release of TXB₂.

A, TXB₂ concentrations in the serosal solution incubated without SNP and carboxy-PTIO (open columns), with 100 μM SNP (filled columns), and with 100 μM SNP plus 200 μM carboxy-PTIO (hatched column) were determined in each mucosa as described in Methods. B, TXB₂ concentrations in the mucosal solution incubated without SNP and ODQ (open columns), with 100 μM SNP (filled columns), and with 100 μM SNP plus 10 μM ODQ (hatched column) were determined. All chemicals were added to the serosal side. n = 4 (A) and 3 (B). *,** P < 0.05 and 0.01, respectively.