Table 1.

Effect of UO126 on the biophysical properties of β1B Ca²⁺ channels expressed in COS-7 cells

	Imax (pA pF−1)			V50,act (mV)			k (mV)
β subunit	Control	UO126	n	Control	UO126	n	Control	UO126	n
β1b	−99 ± 20	−49 ± 11**	11	2 ± 2	2 ± 3	5	3 ± 1	6 ± 1**	5
β2a	−91 ± 18	−71 ± 17**	12	5 ± 1	−1 ± 1***	8	4 ± 1	4 ± 1	8
β2a(C3,4S)	−74 ± 14	−48 ± 9**	11	5 ± 4	3 ± 3	9	4 ± 0.4	5 ± 0.4	9
β3	−80 ± 21	−42 ± 10**	7	6 ± 2	4 ± 3	7	4 ± 1	6 ± 1	7
β4	−70 ± 14	−36 ± 10**	6	4 ± 3	2 ± 2	5	5 ± 0.2	6 ± 0.3*	5
(-)β	−6 ± 1	−6 ± 1	6	29 ± 5	27 ± 2	4	11 ± 2	10 ± 1	4

I_max is the maximum peak current density. Individual current density–voltage plots were fitted with a Boltzmann function:

where V_rev is the reversal potential, V_50,act is the voltage for half-maximal activation of current, g is the conductance and k is the slope factor. Statistical analysis used Student's paired t test. Asterisks denote statistically significant differences as follows:

^*P < 0.05

^**P < 0.01

^***P < 0.001. n is the number of cells tested for each treatment.