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Effect of UO124 on the biophysical properties of β1B Ca2+ channels expressed in COS-7 cells
| Imax (pA pF−1) | V50,act (mV) | k (mV) | |||||||
|---|---|---|---|---|---|---|---|---|---|
| β subunit | Control | UO124 | n | Control | UO124 | n | Control | UO124 | n |
| β1b | −52 ± 10 | −44 ± 7 | 11 | 5 ± 2 | 7 ± 3 | 8 | 5 ± 1 | 6 ± 1 | 8 |
| βb2a | −122 ± 43 | −120 ± 40 | 5 | 9 ± 5 | 6 ± 6 | 4 | 4 ± 1 | 5 ± 1 | 4 |
| β3 | −65 ± 23 | −53 ± 19 | 4 | 10 ± 2 | 9 ± 1 | 3 | 6 ± 1 | 6 ± 0.3 | 3 |
| βb4 | −23 ± 9 | −20 ± 8 | 7 | 13 ± 2 | 10 ± 1 | 5 | 6 ± 0.3 | 6 ± 0.3 | 5 |
All parameters are as previously defined in the legend to Table 1.
