Table 2.
Variable | Group | Baseline | s.e.m. | Theophylline or saline infusion | s.e.m. | Hypoxia | s.e.m. | Recovery | s.e.m. |
---|---|---|---|---|---|---|---|---|---|
PCO2(mmHg) | Control | 46.7 | 0.5 | 47.3 | 0.5 | 42.3b | 0.6 | 46.6 | 0.5 |
Theophylline | 49.2 | 0.7 | 48.5 | 4.2 | 45.3bd | 0.9 | 47.2 | 0.5 | |
Hb (gdl−1) | Control | 9.84 | 0.24 | 10.10 | 0.24 | 10.78a | 0.25 | 9.74 | 0.22 |
Theophylline | 9.38 | 0.21 | 9.34 | 1.02 | 10.30b | 0.20 | 9.64 | 0.17 | |
pH | Control | 7.33 | 0.00 | 7.34 | 0.00 | 7.34 | 0.01 | 7.27b | 0.01 |
Theophylline | 7.32 | 0.01 | 7.33 | 0.00 | 7.30c | 0.01 | 7.24bc | 0.01 | |
Glucose (mg dl−1) | Control | 18.7 | 0.7 | 20.4 | 0.9 | 23.2 | 1.1 | 26.4b | 1.3 |
Theophylline | 18.2 | 1.0 | 19.1 | 1.9 | 25.2b | 1.5 | 28.6b | 1.4 | |
Lactate (mmol l−1) | Control | 1.2 | 0.1 | 1.4 | 0.2 | 4.5b | 0.5 | 5.3b | 0.4 |
Theophylline | 1.3 | 0.1 | 1.4 | 0.1 | 4.6b | 0.7 | 7.2b,c | 0.6 | |
Adenosine (μM) | Control | 1.11 | 0.21 | 1.19 | 0.25 | 1.33 | 0.34 | 1.27 | 0.35 |
Theophylline | 1.13 | 0.16 | 1.09 | 0.16 | 1.29 | 0.20 | 1.21 | 0.24 |
Significant difference from baseline (P < 0.05).
Significant difference from baseline (P < 0.01).
Significant difference from corresponding control value (P < 0.05).
Significant difference from corresponding control value (P < 0.01).