Figure 2. Effect of sarcoplasmic reticulum Ca²⁺ store release or depletion on the cytosolic [Ca²⁺] in renal ASMCs.

A, 10 mm CAF-induced Ca²⁺ transient. B, 10 mm CAF-induced Ca²⁺ transients in the presence of 10 μM RY. C, 10 μM PE-induced Ca²⁺ transient. D, 10 μM PE-induced Ca²⁺ transients and the basal cytosolic [Ca²⁺] increase in the presence of 1 μM thapsigargin. Dashed lines show the resting cytosolic [Ca²⁺]. Arrows indicate elevated cytosolic Ca²⁺.