Figure 5. Effect of sarcoplasmic reticulum Ca²⁺ store depletion on the rate of Mn²⁺ entry in pulmonary ASMCs.

A, 10 mm CAF and 1 μM ANG II effect on fura-2 quench in the presence of 10 μM RY and 10 μM CPA. a.u., arbitrary units. B, 1 μM ANG II effect on fura-2 quench in the presence of 10 μM CPA. C, 10 mm CAF effect on fura-2 quench in the presence of 10 μM RY. D, percentage change in fura-2 quench compared to control. Error bars represent ± s.e.m. Numbers of independent experiments are shown in parentheses. * Significantly different from the change in basal, InsP₃ store-depleted and RY store-depleted quench rates (P < 0.05); one-way ANOVA with a SNK multiple comparison procedure.