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. 2002 Jul 19;543(Pt 3):995–1005. doi: 10.1113/jphysiol.2002.021923

Figure 1. Assessing specificity of suramin (100 pmol) in the NTS.

Figure 1

NTS microinjections of either AMPA (A; 0.4 pmol) or NMDA (B; 4 nmol) induced bradycardia which was similar in magnitude and duration after a microinjection of suramin (100 pmol). In C, the bradycardia evoked by the P2X receptor agonist (α,β-methylene ATP; 10 pmol) was almost completely antagonized by suramin (100 pmol). These findings suggest that 100 pmol suramin in the NTS does not antagonize glutamatergic synapses but does block P2X receptors in the WHBP.