Figure 2. COOH-terminal truncation induces an aberrant gating mode.
Diary plots of single-channel open probability, Po of wild-type Kir1.1a (A) vs. the truncated mutant, Kir1.1a 351X (B). Shown are plots of Po measured in 5 s intervals over the duration of a 3 min recording. Representative channel records corresponding to the indicated time are shown in a and b. Single-channel recordings were obtained in the cell-attached mode (Vm = −80 mV) from oocytes injected with either wild-type or mutant channel cRNA.