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. 2002 Sep 20;544(Pt 3):777–791. doi: 10.1113/jphysiol.2002.026658

Table 1.

Effect of BAPTA on fCavs. [CaSR] relationship at −6 mV

(1) (2) (3) (4) (5) (6) (7)
FCa at −60 mV
Fibre 1500–3000 μm 300–500 μm (3)÷(2) fCa,peak [CaSR]peak (μm) [CaSR]1/2 (μm)
Control experiments with no BAPTA added O29011 0.0151 0.0471 3.12 0.0483 460 954
N01011 0.0149 0.0726 4.87 0.0806 318 840
N02011 0.0075 0.0573 7.64 0.0600 348 944
N07011 0.0284 0.1154 4.06 0.1032 443 864
D04011 0.0146 0.0535 3.66 0.0540 359 727
D07011 0.0639 0.3438 5.38 0.3441 368 969
Mean 0.0241 0.1150 4.79 0.1150 383 883
s.e.m. 0.0084 0.0469 0.66 0.0466 23 38
Experiments in which 8 mm BAPTA was added O05011 0.0093 0.0293 3.15 0.0297 462 1184
O10011 0.0059 0.0378 6.41 0.0408 300 859
O12011 0.0056 0.0225 4.02 — — —
O15011 0.0259 0.0975 3.76 — — —
O16011 0.0160 0.1435 8.97 0.1433 406 1104
Mean 0.0125 0.0661 5.26 0.0713 389 1049
s.e.m. 0.0038 0.0220 1.08 0.0362 48 98

Effect of BAPTA on fCa at –60 mV. The first and second sections give results from control and BAPTA experiments, respectively. Column 1 gives the fibre reference. Column 2 gives the average values of fCa for all of the stimulations whose [CaSR] values before the pulse were in the range 1500–3000 μm. Only values before adding BAPTA are included. Column 3 gives the average values of fCa when [CaSR] was 300–500μm. Column 4 gives the ratio of the value in column 3 to that in column 2. Columns 5,6 and 7 give values of fCa,peak [CaSR]peak and [CaSR]1/2. None of the means in the BAPTA experiments is significantly different from the control value. See text for details. Four ranges are given for the following experimental parameters. The first and second ranges were from the control experiments when [CaSR] was 1500–3000 μm and 300–500 μm, respectively (from stimulations used in columns 2 and 3, respectively). The third and fourth ranges correspond to the first and second ranges, respectively, for the experiments in which BAPTA was added. Time after saponin treatment: 56–101, 116–153, 55–87, 126–226 min; fibre diameter: 97–119, 97–113, 111–143, 103–138 μm; pHR: 6.88–7.11, 6.80–7.05, 6.94–7.10, 6.85–7.10; Ih: –18 to –52, –19 to –64, –21 to –69, –23 to –68 nA; Capp: 0.00861–0.01700, 0.00847–0.001745, 0.01184–0.02089, 0.01288–0.01963 μF; ri: 1.98–3.90, 2.05–3.62, 1.90–2.66, 1.62–2.84 MΩ cm−1.