Figure 7. Responses of ischaemically sensitive and insensitive cardiac afferents to 5-HT before and after tropisetron.

A, bar graph showing discharge activity of seven cardiac afferents during 5 min of myocardial ischaemia, stimulation with 5-HT (40 μg kg⁻¹, LA) and bradykinin (3 μg, LA). B, bar graph showing reproducibility of responses of nine ischaemically sensitive cardiac afferents to repeated LA administration of 5-HT (40 μg kg⁻¹). C, bar graph summarizing responses of six other ischaemically sensitive cardiac afferents to 5-HT (40 μg kg⁻¹, LA) before (-tropisetron) and after (+ tropisetron) treatment with tropisetron (300 μg kg⁻¹, i.v.). Data are presented as means ± s.e.m. * P < 0.05vs. respective control; † P < 0.05, post-tropisetron vs. pre-tropisetron.