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. 2002 Oct 18;545(Pt 1):5–11. doi: 10.1113/jphysiol.2002.031856

Figure 3. Sequence comparison of KChIPs and human frequenin for construction of the KChIP2d-Frq mutation.

Figure 3

A, sequence alignment of KChIP1 (GenBank AAF33682), KChIP2d, KChIP3 (AAF33684) and frequenin (AF186409) representing the region mutated in KChIP2d-Frq. Black shading, amino acids identical in all sequences. Grey shading, amino acids conserved in at least three of the sequences. Bottom sequence illustrates the KChIP2d-Frq mutant. Mutated amino acids are bold and underlined. B, representative recovery waveforms (Vh = −100 mV; same protocol as in Fig. 2) for Kv4.3, Kv4.3 + KChIP2d, and Kv4.3 + KChIP2d-Frq. Calibration bars: 1 μA, 500 ms.