Figure 1. Effect of diclofenac on bradykinin-induced relaxation.

A, original traces of the relaxation induced by bradykinin (0.1 μm) of the contraction induced by the stable thromboxane A₂ mimetic, STA₂, in endothelium-intact strips from a normotensive pregnant woman (a) and from a pre-eclamptic woman (b). Bradykinin was applied for 2 min as indicated by the bars. After recording the control response (Diclofenac(-)),the strip was pretreated for 60 min with the cyclooxygenase inhibitor, diclofenac. STA₂ was then applied in the presence of diclofenac (Diclofenac (+)) and bradykinin was applied. B, summary of the effect of diclofenac on the bradykinin-induced relaxation before (□) and after an application of diclofenac (▪). Results are shown as means ± s.e.m. * P < 0.05 vs. before application of diclofenac (Student's paired t test with an F test). † P < 0.05 vs. normotensive pregnant women (Student's unpaired t test with F test).