Figure 5. Effect of bradykinin on the synthesis of prostacyclin.

Bradykinin (0.1 μm) was applied for 5 min in endothelium-intact strips treated with l-NNA from normotensive pregnant and pre-eclamptic women. Data show the concentration of a stable metabolite of prostacyclin, 6-keto-PGF_1α, in the absence (□) and presence of bradykinin (▪). Results are shown as means ± s.e.m. * P < 0.05 vs. in the absence of bradykinin (Student's unpaired t test with an F test). † P < 0.05 vs. normotensive pregnant women (Student's unpaired t test with an F test).