Table 3.
Cold-and menthol-induced depolarisation and current in cold-sensitive DRG neurones
| Control | n | 10 ± M (−)-menthol | n | 100 ± M (−)-menthol | n | 100 ± M (−)-menthol | n | |
|---|---|---|---|---|---|---|---|---|
| Resting potential at 32°C (mV) | −53.2 ± 6.8 | 48 | −56.9 ± 6.8 | 17 | −46.9 ± 7.4** | 9 | — | — |
| Membrane potential at 37°C (mV) | −54.9 ± 7.1 | 47 | −58.3 ± 7.6 | 17 | −57.4 ± 6.5 | 9 | — | — |
| Cold-induced depolarisation at 18°C (mV) | 28.9 ± 8.1 | 45 | 42.7 ± 10.1* | 17 | 49.7 ± 6.2** | 9 | — | — |
| Depolarisation threshold (°C) | 31.9 ± 5.9 | 46 | 33.3 ± 1.9* | 17 | 36.0 ± 0.9** | 9 | — | — |
| Cold-activated current at 18°(pA) | 137 ± 90 | 63 | 440 ± 395* | 23 | 746 ± 440** | 9 | — | — |
| Cold-activated current threshold (°C) | 31.5 ± 2.7 | 61 | 34.0 ± 2.6* | 23 | 37.1 ± 1.6** | 35 | 35.4 ± 2.1*** | 9 |
*
P < 0.01 from control
**
P < 0.01 from 10 μm (-) menthol
***
P < 0.001 from 100 μm (-) menthol; Student's paired t test.