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. 2002 Oct 4;545(Pt 2):581–593. doi: 10.1113/jphysiol.2002.028423

Figure 7. Ionotropic glutamate receptors (iGluR) mediating glial modulation of sPSC frequency.

Figure 7

A, the sPSC frequency of a Purkinje neuron increased in response to CNQX (5 μm). In the presence of CNQX, stimulation of an adjacent glial cell has no influence on the sPSC frequency. B and C, similar effect of NBQX (5 μm) and KynA (1 mm), which also suppressed the modulation of sPSC frequency following glial stimulation. D, block of metabotropic glutamate receptors with (+)-MCPG (0.5 mm), which did not suppress the glial modulation of synaptic activity. E, a block of NMDA iGluRs with APV (50 μm) also failed to inhibit the glia-induced reduction of neuronal activity. F, histogram summarizing the changes of the sPSC frequency as induced by glial stimulation during a block of AMPA/kainate GluR with CNQX, NBQX or KynA, respectively, a block of NMDA receptors with APV or during a block of mGluRs with (+)-MCPG, indicating the role of iGluRs of the AMPA/kainate type for the synaptic modulation.