Table 1.
Conductivity of the intact epithelium and decrease of gleakbetween 2 and 8 min post lesion
| Control | Cytochalasin D | Butanedione monoxime | Low free[Ca2 +]o | ML-7 | Y-27632 | |
|---|---|---|---|---|---|---|
| Gintact (mS cm−2) | 1.38 ± 0.07 | 15.92 ± 4.55 *** | 3.02 ± 0.39*** | 15.27 ± 2.74 *** | 1.66 ± 0.14n.s. | 1.40 ± 0.09 n.s. |
| (gleak,2min −gleak,8min)/gleak,2min | 61 ± 3% | 3 ± 2%*** | 31 ± 3%*** | 74 ± 5%n.s. | 14 ± 3%*** | 66 ± 4%n.s. |
| n (m) | 24(23) | 7(5) | 10(6) | 7(5) | 8(8) | 8(7) |
Conductivity of intact epithelium, Gintac, apart from apoptosis or edge damage, was measured in the conductance scanning set-up before inflicting a lesion. The decrease in gleak, associated with a single-cell lesion, between 2 and 8 min post lesion was determined. n, number of leaks; m, number of monolayers. Wilcoxon-Mann-Whitney U test with Bonferroni's correction for multiple testing
P > 0.05
P < 0.002.