Table 2.

Screening, vaccine and cost parameters

Parameters	Base case	Ranges	References
Screening characteristics
Screening interval	3 years in ages 25–49 years and 5 years in ages 50–64 years		NHS cervical screening programme 22
Coverage rates of target groups by age (2003)
25–29	74.0%		NHS cervical screening programme 22
30–34	81.0%
35–39	83.7%
40–44	84.0%
45–49	83.8%
50–54	83.2%
55–59	81.4%
60–64	77.3%
Inadequate pap smear results	10%	5% – 20%
Pap Sensitivity for CIN 1/2 Pap sensitivity for CIN 1/2 (LBC)	61%	51% – 80%	Nanda et al23and Karnon et al25
Pap Sensitivity for CIN 3 Pap Sensitivity for CIN 3 (LBC)	65%	65% – 90%	Nanda et al23 and Karnon et al25
Pap Specificity for no CIN Pap Specificity for no CIN (LBC)	95.7%	90% – 99%	Nanda et al25 and Kulasingam et al24
Colposcopy/Biopsy Sensitivity	90%	88% – 100%	Mitchell et al27
Colposcopy/Biopsy Specificity	100%	65% – 100%	Kulasingam et al24 and Karnon et al25
Vaccine characteristics
Vaccine efficacy for all 6, 11, 16, 18 HPV types	98%	85% – 100%	Villa et al5 and Future II 6
Duration of efficacy	Lifetime	From 10 years to lifetime	Olsson et al 28 and Villa et al42
Vaccine coverage	85%	50%–90%	Trotter et al31 and Bramley et al32
Booster coverage		50%	Trotter et al31
Costs
Pap smear	£23.7	£18 – £30	Brown et al 26 Curtis et al38
Colposcopy (with or without biopsy)	£141.69	£113 – £170
Knife cone biopsy of cervix uteri	£290.64	£232 – £349
CIN 1, CIN 2, CIN 3	£313.14	£250 – £376
FIGO I	£12,142	£9,714 – £14,570	Curtis et al38 and Wolstenholme et al37
FIGO II	£22,061	£17,649 – £26,473
FIGO III	£21,785	£17,428 – £26,142
FIGO IV	£23,402	£18,722 – £28,082
Genital warts	£215.73	£172 – £259	Brown et al26 and Curtis et al38
Vaccine cost/dose	£75	£70 – £80
Administration cost/dose	£ 3.4	£0 – £12	Trotter et al31
Booster cost/dose		£75
Administration cost for booster		£10	Curtis et al38
Discount rates
Costs	3.5%	0 – 5%
Benefits	3.5%	0 – 5%