Fig. 1.
General schematic of model reflecting uninfected CD4+ T lymphoblasts (TU), early-stage-infected CD4+ T lymphoblasts (T1), late-stage-infected CD4+ T lymphoblasts (T2), uninfected M cells (MU), early-stage-infected M cells (M1), and late-stage-infected M cells (M2). The death rates of these cell are represented by δTU, δT1, δT2, δMU, δM1, and δM2, respectively. kT and kM define the rates at which T1 transition to T2 and M1 transition to M2, respectively. Free virus (V) is cleared at a rate c and produced by T2 with a burst size of NT and by M2 with burst size NM. λT and λM represent CD4+ T lymphoblast and M cell production. βT and βM reflect virus infectivity with respect to CD4+ T lymphoblasts and M cells.