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. 2008 Mar 14;105(12):4656–4660. doi: 10.1073/pnas.0800043105

Fig. 3.

Fig. 3.

Number of viable bacteria per milliliter of tissue homogenate (cfu/ml) at necropsy in lung and spleen tissues after bacterial challenge of animals immunized with the particles or BCG solution by the different routes (average ± SD, n = 6). The ranking of lung bacterial burden in terms of statistical significance is relative to untreated animals: none > s.c. solution 2 × 106 cfu (P < 0.0001) > pulmonary particles 2 × 105 cfu (P = 0.0002) > pulmonary particles 2 × 106 cfu (P = 0.0003), and relative to animals immunized by the s.c. route: s.c. solution 2 × 106 cfu > pulmonary particles 2 × 105 cfu (P = 0.0002) > pulmonary particles 2 × 106 cfu (P = 0.0036). The ranking of spleen bacterial burden in terms of statistical significance is relative to untreated animals: none > s.c. solution 2 × 106 cfu (P = 0.0002) > pulmonary particles 2 × 105 cfu (P < 0.0001) > pulmonary particles 2 × 106 cfu (P < 0.0001), and relative to animals immunized by the s.c. route: s.c. solution 2 × 106 cfu > pulmonary particles 2 × 106 cfu (P < 0.0001).