Table 1.
Delayed hypersensitivity reactions to 100 TU of PPD in guinea pigs 6 weeks after immunization with the different formulations of BCG by the different routes (average ± SD, n = 6)
| Treatment groups | Route of administration | Dose | Diameter of induration, mm |
|---|---|---|---|
| BCG soln. | s.c. | 2 × 105 cfu | 15.8 ± 3.4 |
| BCG soln. | s.c. | 2 × 106 cfu | 17.0 ± 1.6 |
| BCG part. | s.c. | 2 × 106 cfu | 17.3 ± 1.2 |
| BCG soln. | i.d. | 2 × 106 cfu | 15.8 × 2.9 |
| BCG part. | Pulmonary | 2 × 105 cfu | 10.0 × 2.5* |
| BCG part. | Pulmonary | 2 × 106 cfu | 15.3 ± 3.5 |
| Untreated control | 0 ± 0** |
*, significantly smaller than the untreated control (P < 0.05).
**, significantly smaller than any other treatment (P < 0.05).