Fig. 4.

Model illustrating how myoV and kinesin act as molecular tethers for each other to enhance processivity inside the cell. MyoV and kinesin are bound to the same cargo. Through an electrostatic interaction (+) between myoV and the microtubule (MT), the run length for kinesin is extended beyond the point at which kinesin alone would have terminated its run. This effective tether contributes to an enhancement of kinesin's run length. The reciprocal mechanism is illustrated on actin with kinesin serving as the tether for myoV.