Fig. 4.

Abnormal CBF changes upon ischemic challenge in Notch 3 knockout mice. Representative tracings showing the time-course of CBF changes after dMCAO (at time 0) in severe (black), moderate (green), or mildly ischemic cortex (red) in WT and Notch 3^−/− (N3^−/−) mice. Black dots indicate spontaneous peri-infarct depolarizations (PIDs). Notch 3^−/− mice developed more frequent PIDs; however, the characteristic transient hypoperfusion response observed in WT during the PIDs (arrows) was absent in Notch 3^−/− mice.