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. 2008 Mar 24;180(6):1101–1114. doi: 10.1083/jcb.200710052

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Copyright © 2008, The Rockefeller University Press

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Figure 8. — A kinetic framework for centromere assembly. Relative amounts of different nuclear pools of centromere proteins are plotted against cell cycle progression. “Dilution” refers to depletion of centromere-bound CENP-A and CENP-I during DNA replication because these proteins do not dynamically exchange. Hence, FRAP of CENP-A and CENP-I in G1 and S phase, respectively, can be regarded as “loading.” “Stably bound” and “dynamic exchange” indicate those relative populations of centromere proteins exhibiting no exchange over hours or complete turnover within seconds or minutes at kinetochores, respectively. M, G1, S, and G2: respective phases of the cell cycle.