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. 2008 Mar 24;180(6):1233–1244. doi: 10.1083/jcb.200709134

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Copyright © 2008, The Rockefeller University Press

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Figure 7. — Coupling with myosin in the lamella. (A) Withdrawal and integration of a filopodium into actomyosin network of lamella. Cell was transfected with mCherry-actin and EGFP-myosin regulatory light chain. Arrows indicate a filopodium that first became kinked and was then drawn into the lamella with the progressive accumulation of myosin and the eventual transition into a stress fiber bundle. Times are given in minutes and seconds. See Video 6 (available at http://www.jcb.org/cgi/content/full/jcb.200709134/DC1). (B) Inhibition of myosin contractility with 50 μM blebbistatin. CAR fibroblast transfected with mCherry-actin. Filopodia formation was not inhibited and filopodia translocated into the lamella (arrowheads) but did not form contractile bundles. See Video 7.