Figure 3.

(A) Disorder in the interface regions of singlish- and multi-interface hubs. (Wilcoxon ranksum test, P=0.4). (B) Disorder of the binding partner of singlish- and multi-interface hubs (Wilcoxon ranksum test, P=4.5e−5). BIOGRID data are reported in the boxplot. Similar results were found for Kim et al (2006) and Batada et al (2006) data sets (Supplementary Figure S5). (C) Schematic representation of disorder in singlish-interface hubs. Singlish-interface hubs have large portions of disordered regions (painted in gray). However, the interface is itself is highly structured (painted in black). One reason for the disorder in the bulk of the protein is the fact that singlish-interface hubs often are targeted by kinases. On the other hand, they tend to be kinases themselves and target disordered regions in other proteins.