Table 2. Odds ratios for breast cancer risk by tumor grade^*.

Locus			Grade 1			Grade 2			Grade 3			Obs.	Adj.
SNP	Genotype	Controls	N	OR**	95% CI	N	OR**	95% CI	N	OR**	95% CI	P***	P****
FGFR2	GG	8916	979	1.00		2368	1.00		1686	1.00
rs2981582	AG	10988	1627	1.32	1.21–1.43	3879	1.31	1.24–1.39	2344	1.12	1.04–1.20
	AA	3389	696	1.83	1.64–2.03	1521	1.68	1.55–1.81	853	1.32	1.20–1.44
	per allele			1.35	1.28–1.42		1.30	1.25–1.35		1.14	1.09–1.19	10−8	<0.001
TNRC9	GG	12073	1497	1.00		3620	1.00		2382	1.00
rs3803662	AG	8570	1436	1.31	1.21–1.42	3285	1.26	1.19–1.33	1978	1.15	1.08–1.23
	AA	1648	340	1.49	1.31–1.70	775	1.45	1.32–1.59	471	1.33	1.19–1.49
	per allele			1.25	1.19–1.33		1.22	1.18–1.27		1.16	1.10–1.21	0.018	0.50
MAP3K1	TT	12218	1650	1.00		3890	1.00		2478	1.00
rs889312	GT	9316	1371	1.12	1.04–1.21	3217	1.11	1.05–1.17	1997	1.07	1.00–1.15
	GG	1767	267	1.18	1.03–1.36	679	1.26	1.15–1.39	429	1.23	1.09–1.38
	per allele			1.10	1.04–1.17		1.12	1.07–1.16		1.09	1.04–1.15	0.91	1.00
8q24	AA	6794	940	1.00		2163	1.00		1505	1.00
rs13281615	AG	9335	1456	1.15	1.05–1.26	3266	1.11	1.04–1.18	2063	1.01	0.94–1.09
	GG	3185	593	1.42	1.27–1.59	1329	1.35	1.25–1.47	783	1.14	1.03–1.26
	per allele			1.18	1.12–1.25		1.16	1.11–1.20		1.06	1.01–1.11	10−4	0.016
LSP1	AA	11239	1549	1.00		3669	1.00		2287	1.00
rs381798	AG	9923	1409	1.07	0.99–1.16	3314	1.04	0.99–1.10	2145	1.09	1.02–1.16
	GG	2100	333	1.24	1.09–1.41	792	1.21	1.10–1.32	476	1.17	1.04–1.30
	per allele			1.10	1.04–1.16		1.08	1.04–1.12		1.08	1.03–1.14	0.77	1.00

*: Analyses excluded data from three studies (MEC, NHS and TBCS) without information on tumor grade.

**: Per-allele OR adjusted for study.

***: P value for heterogeneity of ORs from case-only analyses adjusted by study.

****: Permutation adjusted P for heterogeneity