Table 4. Multivariate Cox proportional hazards analysis of genetic polymorphisms in relation to overall survival following breast cancer diagnosis, by ER status*.
| Unadjusted** | Adjusted**** | |||||||
| Locus | SNP | HR** | 95% CI | Obs P | Adj P*** | HR** | 95% CI | Obs P |
| All tumors | ||||||||
| FGFR2 | rs2981582 | 0.98 | 0.91–1.05 | 0.56 | 1.00 | 1.01 | 0.92–1.11 | 0.82 |
| TNRC9 | rs3803662 | 1.05 | 0.96–1.15 | 0.26 | 1.00 | 1.06 | 0.95–1.19 | 0.31 |
| MAP3K1 | rs889312 | 1.02 | 0.95–1.11 | 0.54 | 1.00 | 1.03 | 0.93–1.15 | 0.52 |
| 8q24 | rs13281615 | 0.90 | 0.83–0.97 | 0.009 | 0.32 | 0.92 | 0.83–1.01 | 0.084 |
| LSP1 | rs381798 | 0.99 | 0.92–1.07 | 0.88 | 1.00 | 1.03 | 0.93–1.14 | 0.55 |
| ER positive tumors | ||||||||
| FGFR2 | rs2981582 | 1.00 | 0.90–1.11 | 0.98 | 1.03 | 0.92–1.16 | 0.62 | |
| TNRC9 | rs3803662 | 1.02 | 0.89–1.16 | 0.82 | 1.00 | 0.86–1.15 | 0.97 | |
| MAP3K1 | rs889312 | 0.99 | 0.88–1.11 | 0.82 | 0.99 | 0.87–1.13 | 0.91 | |
| 8q24 | rs13281615 | 0.88 | 0.78–0.99 | 0.039 | 0.89 | 0.78–1.01 | 0.068 | |
| LSP1 | rs381798 | 1.09 | 0.98–1.23 | 0.12 | 1.07 | 0.94–1.21 | 0.32 | |
| ER negative tumors | ||||||||
| FGFR2 | rs2981582 | 0.99 | 0.85–1.15 | 0.87 | 0.98 | 0.84–1.14 | 0.78 | |
| TNRC9 | rs3803662 | 1.19 | 0.99–1.43 | 0.071 | 1.19 | 0.98–1.44 | 0.076 | |
| MAP3K1 | rs889312 | 1.15 | 0.98–1.35 | 0.08 | 1.11 | 0.94–1.32 | 0.22 | |
| 8q24 | rs13281615 | 0.95 | 0.81–1.11 | 0.48 | 0.96 | 0.82–1.13 | 0.64 | |
| LSP1 | rs381798 | 0.95 | 0.81–1.11 | 0.49 | 0.97 | 0.82–1.15 | 0.74 | |
*: Analyses by ER status included data from 12 studies with information on vital status and ER status (CGPS, CNIO-BCS, HABCS, HEBCS, KBCP, kConFab, LUMCBCS, MCCS, PBCS, SASBCS, SBCS, SEARCH).
**: Per-allele hazard ratios (HR) and observed P values are adjusted for study. Allele changes are (common>rare based on frequencies in European populations): G>A for rs2981582; G>A for rs3803662; T>G for rs889312; A>G for rs13281615 and A>G for rs381798.
***: Permutation adjusted P values.
****: Per-allele hazard ratios (HR) and observed P values are adjusted for study, age at diagnosis (continuous), ER status and grade (continuous). Analyses limited to 11 studies with ER and grade information (CGPS, CNIO-BCS, HABCS, HEBCS, KBCP, LUMCBCS, MCCS, PBCS, SASBCS, SBCS, SEARCH).
The P values for the interaction between ER status and genotype adjusted for study, grade and age at diagnosis are: 0.60, 0.15, 0.29, 0.45, 0.38 for rs2981582, rs3803662, rs889312, rs13281615, rs381798, respectively.