Fig. 2.

Clozapine attenuates PPI deficits and hyperactivity in BACE^−/−mice. Effect of clozapine (2 mg/kg, i.p.) on hyperactivity (A), PPI (B), and working-memory deficits (C) in BACE1^−/− mice. PPI shows an overall percentage of inhibition (±SEM) observed in four types of trials with two different levels of startle and prepulse stimuli (Fig. S3). Abbreviations and signs are as in Fig. 1 (n = 8–12 per genotype per treatment).