Fig. 4.

Acute CORT treatment increased anxiety in elevated plus maze. (A) CORT-treated animals (n = 18) exhibited reduced open-arm exploration in terms of both open-arm entries (left set of bars) and open-arm time (right set of bars) compared with vehicle-treated animals (n = 18). *, P < 0.05 (Student's t test). Both vehicle- and CORT-treated animals exhibited similar locomotor activity as measured in closed-arm entries of elevated plus maze (B). Chronic CORT (n = 17) and vehicle (n = 11) treatment resulted in similar open-arm exploration as evident from both the number of open arm entries (C, left bars) and open arm time (C, right bars) along with similar locomotion (D). Values are mean ± SEM.