Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Inhibition of GST-Abl and GST-AblT315I enzymatic activity by SGX393. Inhibition of in vitro autophosphorylation of purified GST-Abl and GST-AblT315I by imatinib, nilotinib, dasatinib, and SGX393. After incubation of purified, tyrosine-dephosphorylated enzyme with the indicated inhibitors in the presence of [γ-32P]-ATP and separation by gel electrophoresis, signal intensity was measured by autoradiography.
