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Inhibition of tyrosine phosphorylation by SGX393 in primary Bcr-AblT315I cells. Bcr-AblT315I CML lymphoid blast crisis (CML L-BC) mononuclear cells incubated with SGX393, imatinib, dasatinib, or nilotinib overnight were subjected to immunoblot analysis with a total CrkL-specific antibody (Upper), and the ratio of phosphorylated CrkL to nonphosphorylated CrkL was determined by densitometry (Lower).
