Table 1.
IC50 and IC90 values for SGX393 in cellular proliferation assays
| Cell Lines | SGX393 |
||
|---|---|---|---|
| IC50, nM | Fold IC50 | IC90, nM | |
| Ba/F3 cells | |||
| Native Bcr-Abl | 12 | 1.0 | 84 |
| M244V | 21 | 1.8 | 47 |
| G250E | 619 | 54 | 3,609 |
| Q252H | 241 | 21 | 894 |
| Y253F | 696 | 60 | 3,548 |
| Y253H | 176 | 15 | 440 |
| E255K | 207 | 18 | 585 |
| E255V | 2,210 | 191 | 4,795 |
| F311L | 250 | 22 | 465 |
| T315A | 12 | 1.0 | 39 |
| T315I | 7.3 | 0.6 | 28 |
| F317L | 598 | 52 | 3,242 |
| M351T | 15 | 1.3 | 117 |
| F359V | 10 | 0.9 | 47 |
| V379I | 13 | 1.1 | 56 |
| L387M | 12 | 1.0 | 57 |
| H396P | 5.6 | 0.5 | 15 |
| H396R | 18 | 1.5 | 49 |
| Parental | 3,632 | 314 | >5,000 |
| CML leukemia cells | |||
| K562 | 13 | NA | 24 |
| BV173 | 16 | NA | 70 |
| Non-CML leukemia cells | |||
| CMK | 3,129 | NA | >5,000 |
| CTV | 2,088 | NA | 4,742 |
| HL60 | 3,621 | NA | >5,000 |
| Marimo | 3,986 | NA | >5,000 |