Table 2.

Systolic and diastolic function in mice

Variable	Tbx5+/+	Tbx5Vdel/+	Tbx5Vdel/+;PLN−/−	PLN−/−
Body weight, g	29.1 ± 1.0	27.8 ± 1.1	26.1 ± 4.4	27.9 ± 6.5
Heart rate, min−1	403 ± 10	395 ± 9	422 ± 39	440 ± 32
LV end-diastole
AW, mm	0.85 ± 0.03	0.92 ± 0.02	0.99 ± 0.06	0.82 ± 0.03
EDD, mm	4.22 ± 0.08	3.79 ± 0.09*‡	4.02 ± 0.10	4.32 ± 0.14*
PW, mm	0.72 ± 0.02	0.71 ± 0.03	0.80 ± 0.07	0.71 ± 0.03
LV end-systole
AW, mm	1.20 ± 0.05	1.28 ± 0.04	1.26 ± 0.08	1.08 ± 0.08
ESD, mm	2.89 ± 0.11	2.71 ± 0.13	2.82 ± 0.19	2.94 ± 0.09
PW, mm	0.98 ± 0.04	0.97 ± 0.06	1.15 ± 0.08	0.99 ± 0.03
LV FS, %	35.1 ± 2.5	32.1 ± 0.13	32.6 ± 1.2	36.7 ± 0.9
E wave	816 ± 29	670 ± 54*†‡	820 ± 31	854 ± 8
A wave	418 ± 23	527 ± 21*	479 ± 22	458 ± 10
E/A	2.05 ± 0.07	1.27 ± 0.08*†‡	1.71 ± 0.07*	1.87 ± 0.05
IVRT	15.7 ± 0.57	19.1 ± 0.39*†‡	14.9 ± 0.45	13.8 ± 0.33
DT	69.7 ± 3.4	47.7 ± 1.0*†‡	72.2 ± 3.3	75.3 ± 1.1
IVRT/DT	0.22 ± 0.01	0.40 ± 0.01*†‡	0.20 ± 0.01	0.18 ± 0.01

Cardiac M mode and Doppler ultrasound measurements at 8–10 weeks of age (mean ± SEM); n = 10–12; *, P < 0.05 vs. WT; ^†, P < 0.05 vs. Tbx5^Vdel/+;PLN^−/−; ^‡, P < 0.05 vs PLN^−/−.