Table 5.
Systolic and diastolic function in humans
| HOS (n = 8) | Controls (n = 8) | P | |
|---|---|---|---|
| Age, years | 11.25 ± 5.1 | 15.2 ± 6.8 | 0.14 |
| Body weight, kg | 53.8 ± 26.1 | 44.2 ± 18.8 | 0.31 |
| Heart rate, beats/min | 96 ± 17 | 99 ± 11 | 0.8 |
| Shortening fraction, % | 35 ± 4.1 | 34.7 ± 3.2 | 0.89 |
| Mitral valve inflow | |||
| E wave, cm/s | 123 ± 22 | 159 ± 21 | 0.03 |
| A wave, cm/s | 45 ± 8 | 52 ± 8 | 0.026 |
| E/A ratio | 2.8 ± 0.7 | 2 ± 0.3 | 0.003 |
| Deceleration time | 170 ± 18 | 159 ± 21 | 0.24 |
| IVRT | 69 ± 10 | 62 ± 14 | 0.13 |
| Tissue Doppler | |||
| MV-E′, cm/s | 18.1 ± 4.3 | 21.2 ± 3.2 | 0.049 |
| MV-A′, cm/s | 5.5 ± 2.3 | 7.1 ± 1.1 | 0.06 |
| MV-E/E′, cm/s | 7.1 ± 2.7 | 4.9 ± 0.75 | 0.03 |
| IVS-E′, cm/s | 11 ± 1.5 | 16 ± 2.9 | 0.005 |
| IVS-A′, cm/s | 4.8 ± 1.9 | 6.4 ± 1.2 | 0.05 |
| IVS-E/E′, cm/s | 11.3 ± 3 | 4.9 ± 0.77 | 0.0001 |
E wave, early mitral inflow; A wave, late mitral inflow; IVRT, isovolumic relaxation time; MV-E′ and MV-A′, mitral annulus early (E′) and late (A′) myocardial velocities; IVS-E′ and IVS-A′, interventricular septum early (E′) and late (A′) myocardial velocities; E/E′ ratio, inflow velocity divided by the tissue Doppler velocity.