Table 2.

Allo or S-NFLX blocks the increased duration of contextual freezing time in socially isolated but not in group-housed mice

Drug treatment	Freezing time (sec/5 min)
	Group housed	Socially isolated
Vehicle	90 ± 5.1	148 ± 4.3*
Allo (8 μmol/kg s.c.)	105 ± 11	108 ± 3.0
Allo (16 μmol/kg s.c.)	91 ± 4.9	88 ± 2.8
S-NFLX (0.45 μmol/kg i.p.)	92 ± 11	110 ± 6.6
S-NFLX (0.9 μmol/kg i.p.)	85 ± 6.1	96 ± 9.3
S-NFLX (1.8 μmol/kg i.p.)	98 ± 8.7	80 ± 4.2

Allo or S-NFLX was injected 45 min before the training session. Each value is the mean ± SEM of five mice.

*, P < 0.01 in socially isolated compared with their respective group housed mice (Student's t test).